A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease
| Autor: | Marco Aurélio Scarpinella Bueno, Andrea Tiemi Kondo, Luiz Fernando Alves Lima Mantovani, Polianna Mara Rodrigues de Souza, Andrea Z Pereira, Henrique Grunspun, Ricardo Hellman, Wilson L Pedreira, Eduardo Juan Troster, Nelson Hamerschlak |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Blood transfusion business.industry lcsh:RC633-647.5 medicine.medical_treatment Case Report General Medicine Hematopoietic stem cell transplantation Disease lcsh:Diseases of the blood and blood-forming organs Sister Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis hemic and lymphatic diseases medicine Bone marrow Sibling Complication business Survival rate 030215 immunology |
| Zdroj: | Case Reports in Hematology, Vol 2017 (2017) Case Reports in Hematology |
| ISSN: | 2090-6579 2090-6560 |
| Popis: | Hematopoietic stem cell transplantation (HSCT) is an important treatment option for children with severe and refractory sickle cell disease (SCD) with debilitating clinical complications. HSCT with cells from the bone marrow of a HLA-identical sibling used in SCD has a low mortality risk, high cure rate, and high event-free survival rate after a median follow-up of 5-6 years. However, matched donors are found in only about 20% of the patients. A boy aged 8 years with SCD had a sister |
| Databáze: | OpenAIRE |
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