Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology
| Autor: | Martha Kazimierczak, Juan Irure-Ventura, Marcos López-Hoyos, Carmen Lage, Manuel Rubén Sánchez-Crespo, Pascual Sánchez-Juan, María Puerto Alcalde-Hierro, María Ángeles Villanueva-Eguaras, Catherine N. Widmann, Andrea Fernández-Rodríguez, Andrea González-Suárez, Frederic Brosseron, María Isabel Sampedro-González, Michael T. Heneka, Sara López-García, Ana Pozueta, María García-Martínez, Eloy Rodríguez-Rodríguez, Marta Drake-Pérez, María Bravo-González |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty metabolism [Amyloid beta-Peptides] Plaque Amyloid Neuropsychological Tests cerebrospinal fluid surgery 03 medical and health sciences 0302 clinical medicine Visual memory pathology [Brain] 030202 anesthesiology medicine Humans Dementia Orthopedic Procedures Cumulative incidence ddc:610 pathology [Plaque Amyloid] Neuropsychological assessment Aged Aged 80 and over Memory Disorders Amyloid beta-Peptides medicine.diagnostic_test business.industry General Neuroscience Brain biomarkers Cognition General Medicine Perioperative medicine.disease etiology [Memory Disorders] Surgery adverse effects [Orthopedic Procedures] Psychiatry and Mental health Clinical Psychology Orthopedic surgery Disease Progression complications [Plaque Amyloid] Female Geriatrics and Gerontology business Alzheimer’s disease Neurocognitive 030217 neurology & neurosurgery dementia |
| Zdroj: | Journal of Alzheimer's disease 79(2), 863-874 (2021). doi:10.3233/JAD-191229 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-191229 |
| Popis: | Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer’s disease (AD) might predispose to cognitive deterioration after surgery. Objective: To analyze the effect of amyloid-β on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects. Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers. Results: Cumulative incidence of PND was 55.2%during a mean follow-up of nine months. The most affected cognitive domains were executive function and constructional praxis. The presence of abnormal levels of amyloid-β was associated to a postoperative impairment in verbal and visual memory tests. According to their AD biomarker profile, participants were categorized as either Amyloid Positive (A+) or Amyloid Negative (A-). The incidence of PND did not differ between both groups. The A- group showed a tendency similar to the global sample, worsening in executive function tests and improving on memory scales due to practice effects. In contrast, the A + group showed a notable worsening on memory performance. Conclusion: Our findings support the hypothesis that surgery may promote or accelerate memory decline in cognitively asymptomatic subjects with brain amyloid-β deposits. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|