Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses
| Autor: | James S. Hagood, Tanya A. Rege |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cell signaling
Integrins Cell Survival medicine.medical_treatment Apoptosis Models Biological Article 03 medical and health sciences Mice 0302 clinical medicine Membrane Microdomains medicine Cell Adhesion Animals Autocrine signalling Cell adhesion Molecular Biology Thy-1 Lipid rafts Cells Cultured 030304 developmental biology Cell Proliferation 0303 health sciences GPI anchor biology Growth factor Tyrosine kinases Cell Biology Protein-Tyrosine Kinases 3. Good health Cell biology Cytokine 030220 oncology & carcinogenesis Cancer research biology.protein Cytokines Intercellular Signaling Peptides and Proteins Thy-1 Antigens Neural cell adhesion molecule Signal transduction Platelet-derived growth factor receptor Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763(10):991-999 |
| ISSN: | 0167-4889 |
| DOI: | 10.1016/j.bbamcr.2006.08.008 |
| Popis: | Thy-1 is a 25–37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell activation, neurite outgrowth, apoptosis, tumor suppression, wound healing, and fibrosis. To mediate these diverse effects, Thy-1 participates in multiple signaling cascades. In this review, we discuss Thy-1 signaling primarily in non-immunologic cell types, including neurons, mesangial cells, ovarian cancer cells, nasopharyngeal carcinoma cells, endothelial cells, and fibroblasts. We review the current literature regarding Thy-1 signaling via integrins, protein tyrosine kinases, and cytokines and growth factors; and the roles of these signaling pathways in cellular adhesion, apoptosis, cell proliferation, and cell adhesion and migration. We also discuss the role of Thy-1 localization to lipid rafts, and of the GPI anchor in Thy-1 signaling. Ongoing research on the mechanisms of Thy-1 signaling will add to our understanding of the diverse physiologic and pathologic processes in which Thy-1 plays a role. |
| Databáze: | OpenAIRE |
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