Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
| Autor: | Murielle Bochud, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, François R Jornayvaz, Vincent Mooser |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Leptin
Male Endocrinology Diabetes and Metabolism Type 2 diabetes Body composition Body fat percentage 0302 clinical medicine Medicine 030212 general & internal medicine Original Investigation Metabolic Syndrome 2. Zero hunger Diabetes Infant Low Birth Weight/blood Middle Aged 3. Good health Obesity/blood/etiology Adult Aged Body Composition Cross-Sectional Studies Diabetes Mellitus/blood Diabetes Mellitus/etiology Exercise Female Humans Insulin Resistance/physiology Leptin/blood Metabolic Syndrome X/blood Obesity/blood Obesity/etiology Switzerland Adiponectin medicine.symptom Cardiology and Cardiovascular Medicine medicine.medical_specialty Birth weight 030209 endocrinology & metabolism 03 medical and health sciences Insulin resistance Internal medicine Diabetes Mellitus/blood/etiology Diabetes Mellitus Obesity Cross-sectional study business.industry Infant Low Birth Weight medicine.disease Low birth weight Endocrinology Insulin Resistance business Body mass index |
| Zdroj: | Cardiovascular diabetology, vol. 15, pp. 73 Cardiovascular Diabetology, Vol. 15 (2016) P. 73 Cardiovascular Diabetology |
| ISSN: | 1475-2840 |
| Popis: | Background Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess the relationships between birth weight and markers of glucose homeostasis or obesity in adults. Methods Cross-sectional population-based study on 1458 women and 1088 men aged 35–75 years living in Lausanne, Switzerland. Birth weight was self-reported and categorized into ≤2.5, 2.6–3.5, 3.6–4.0 and >4.0 kg. Body composition was assessed by bioimpedance. Leptin and adiponectin levels were measured by ELISA. Results Women with low birth weight (≤2.5 kg) had higher levels of fasting plasma glucose, insulin, HOMA, diabetes and metabolic syndrome; a non significant similar trend was seen in men. In both genders, height increased with birth weight, whereas a U-shaped association was found between birth weight and body mass index, waist circumference and body fat percentage. After adjusting for age, smoking status, physical activity and fat mass, an inverse association was found between leptin and birth weight categories: adjusted mean ± standard error 17.3 ± 0.7, 16.2 ± 0.3, 15.6 ± 0.5 and 14.0 ± 0.8 ng/dL for birth weight categories ≤2.5, 2.6–3.5, 3.6–4.0 and >4.0 kg, respectively, in women (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink