T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer
| Autor: | John L. McCall, Vicky Phillips, Michael A. Black, Roslyn A. Kemp, Han-Seung Yoon, Ahmad Anjomshoaa, Anthony E. Reeve |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Oncology Cancer Research medicine.medical_specialty Colorectal cancer T cell Priming (immunology) T-Lymphocytes Regulatory lcsh:RC254-282 Immunoenzyme Techniques Immune system T-Lymphocyte Subsets Internal medicine medicine Humans Aged Neoplasm Staging business.industry Research Interleukin-2 Receptor alpha Subunit FOXP3 Forkhead Transcription Factors Prognosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.anatomical_structure Immunology Immunohistochemistry Female Lymph Nodes Lymph Neoplasm Recurrence Local Colorectal Neoplasms business CD8 |
| Zdroj: | Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 78 (2011) Journal of Experimental & Clinical Cancer Research : CR |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/1756-9966-30-78 |
| Popis: | Background The immune response has been proposed to be an important factor in determining patient outcome in colorectal cancer (CRC). Previous studies have concentrated on characterizing T cell populations in the primary tumour where T cells with regulatory effect (Foxp3+ Tregs) have been identified as both enhancing and diminishing anti-tumour immune responses. No previous studies have characterized the T cell response in the regional lymph nodes in CRC. Methods Immunohistochemistry was used to analyse CD4, CD8 or Foxp3+ T cell populations in the regional lymph nodes of patients with stage II CRC (n = 31), with (n = 13) or without (n = 18) cancer recurrence after 5 years of follow up, to determine if the priming environment for anti-tumour immunity was associated with clinical outcome. Results The proportions of CD4, CD8 or Foxp3+ cells in the lymph nodes varied widely between and within patients, and there was no association between T cell populations and cancer recurrence or other clinicopathological characteristics. Conclusions These data indicate that frequency of these T cell subsets in lymph nodes may not be a useful tool for predicting patient outcome. |
| Databáze: | OpenAIRE |
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