Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H-pyridazinon-2-yl]acetamides
| Autor: | Murat Sukuroglu, M. Fethi Şahin, Esra Küpeli, Serdar Ünlü, Burcu Çaliskan Ergün, Erdem Yesilada, Erden Banoglu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Analgesics
medicine.drug_class Organic Chemistry Analgesic Anti-Inflammatory Agents Pyrazole Pharmacology Anti-inflammatory Carrageenan Pyridazines chemistry.chemical_compound Acetic acid Mice chemistry Indometacin In vivo Amide Drug Discovery Acetamides medicine Molecular Medicine Animals Pyrazoles medicine.drug |
| Popis: | A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|