Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research
| Autor: | Maria da Glória Alves, Alba Lucínia Peixoto Rangel, Dolores E. Hill, Flávia Pereira Vieira, Lilian Maria Garcia Bahia-Oliveira, Livia Mattos Martins, Jitender P. Dubey |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Veterinary medicine lcsh:QR1-502 Protozoan Proteins Antibodies Protozoan Fresh Water lcsh:Microbiology Serology Seroepidemiologic Studies Waterborne Diseases TgERP Child Aged 80 and over biology Waterborne diseases Articles Middle Aged Water collection hydrogeology Female Toxoplasma Brazil Toxoplasmosis Microbiology (medical) Adult lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Toxoplasma gondii oocysts Antigens Protozoan Enzyme-Linked Immunosorbent Assay Young Adult geomedicine parasitic diseases medicine Seroprevalence Animals Humans Aged groundwater contamination biology.organism_classification medicine.disease Toxoplasmosis Animal Chickens Groundwater vulnerability |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 110, Iss 7, Pp 929-935 (2015) Memórias do Instituto Oswaldo Cruz, Volume: 110, Issue: 7, Pages: 929-935, Published: NOV 2015 |
| ISSN: | 1678-8060 |
| Popis: | We present a set of data on human and chicken Toxoplasma gondii seroprevalence that was investigated and analysed in light of groundwater vulnerability information in an area endemic for waterborne toxoplasmosis in Brazil. Hydrogeological assessment was undertaken to select sites for water collection from wells for T. gondii oocyst testing and for collecting blood from free-range chickens and humans for anti-T. gondii serologic testing. Serologic testing of human specimens was done using conventional commercial tests and a sporozoite-specific embryogenesis-related protein (TgERP), which is able to differentiate whether infection resulted from tissue cysts or oocysts. Water specimens were negative for the presence of viable T. gondii oocysts. However, seroprevalence in free-range chickens was significantly associated with vulnerability of groundwater to surface contamination (p < 0.0001; odds ratio: 4.73, 95% confidence interval: 2.18-10.2). Surprisingly, a high prevalence of antibodies against TgERP was detected in human specimens, suggesting the possibility of a continuous contamination of drinking water with T. gondii oocysts in this endemic setting. These findings and the new proposed approach to investigate and analyse endemic toxoplasmosis in light of groundwater vulnerability information associated with prevalence in humans estimated by oocyst antigens recognition have implications for the potential role of hydrogeological assessment in researching waterborne toxoplasmosis at a global scale. |
| Databáze: | OpenAIRE |
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