Effective melatonin protection of burn-induced hepatic disorders in rats
| Autor: | Minka Hristova, Stoyanka Tancheva, G. Bekyarova, Yordanka Bratchkova |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
hepatic proteins serum albumin Serum albumin melatonin liver Melatonin burns chemistry.chemical_compound serum cholinesterase Internal medicine morphology Medicine Cholinesterase biology business.industry General Medicine Malondialdehyde Endocrinology Vacuolization chemistry Apoptosis hepatic malondialdehyde biology.protein Hepatic stellate cell serum gamma-glutamyl transpeptidase business Total body surface area medicine.drug |
| Zdroj: | Open Medicine, Vol 7, Iss 4, Pp 533-538 (2012) |
| ISSN: | 2391-5463 |
| DOI: | 10.2478/s11536-012-0006-z |
| Popis: | We studied the effect of melatonin on morphological and functional disorders using serum markers of liver dysfunction such as cholinesterase and gamma glutamyl transpeptidase, hepatic protein content and malondialdehyde in a burned-rat model. Melatonin (10 mg/kg (−1), i.p) was administered immediately and then 12 h after 30% of total body surface area burns of male Wistar rats. The burns induced an increase of hepatic malondialdehyde levels by 166% (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|