THE ROLE OF HYDROXYCHLOROQUINE AS MONOTHERAPY IN MANAGING EARLY UNDIFFERENTIATED ARTHRITIS: A PROSPECTIVE HOSPITAL-BASED STUDY
| Autor: | Mutwaly Defealla Yousif Haron, Ziryab Imad Taha Mahmoud, Mohammed Altyb Alshykh, Abdelkareem A. Ahmed, Sherihan Mohammed Elkundi Osman, Mustafa Mohamed Ali Hussein, Elnour Mohammed Elagib, Mohammed Elmujtba Adam Essa |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Medicine (General) hydroxychloroquine medicine.diagnostic_test business.industry Incidence (epidemiology) Arthritis middle age group Physical examination Hydroxychloroquine monotherapy medicine.disease Undifferentiated arthritis R5-920 Erythrocyte sedimentation rate Internal medicine Joint pain Rheumatoid arthritis early undifferentiated arthritis medicine medicine.symptom business medicine.drug |
| Zdroj: | Global Journal of Public Health Medicine, Vol 1, Iss 2, Pp 52-62 (2019) |
| ISSN: | 2664-4657 |
| Popis: | Introduction: Early undifferentiated arthritis (EUA) is a common form of arthritis comprising, joint pain, stiffness and swelling with no definitive diagnosis. Patients of EUA can progress to other forms of rheumatic arthropathies such as rheumatoid arthritis or remain in the same form or spontaneously disappear. The main focus of this study is to explore the potential effect of hydroxychloroquine (HCQ) in management of EUA as a monotherapy treatment. Methods: This is a prospective hospital-based study which was conducted in Almwada hospital in Khartoum, Sudan. The study included thirty patients of EUA. Full clinical examination and history were done by a rheumatologist, and all the related investigations were obtained, and they all received HCQ after EUA diagnosis has been established. Result: The study shows that 96% of the patients responded well to the treatment and 10% had their duration of treatment doubled to show a favorable response. We also found that female patients weremore commonly affected than male ones with higher incidence among middle aged as compared to others. After treatment with HCQ, 86.6% of the patients showed average mean decrease in erythrocyte sedimentation rate (ESR) by 44%, the other 13.4%, even though they were symptoms free after treatment they showed increased level of ESR by 30% average. Conclusion: In the present study we found out most of the EUA patients are well responded to the HCQ treatment, and most of them respond from the first course of treatment, the study also shows higher incidence among female in compared to male. |
| Databáze: | OpenAIRE |
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