The effects of nitrous oxide on left ventricular systolic and diastolic performance before and after cardiopulmonary bypass: evaluation by computer-assisted two-dimensional and Doppler echocardiography in patients undergoing coronary artery surgery
| Autor: | Sven-Erik Ricksten, Erik Houltz, Tomas Gustavsson, Milocco I, Ake Hellstrom, Kenneth Caidahl |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Cardiac output medicine.medical_specialty Mean arterial pressure Systole Diastole Nitrous Oxide Blood Pressure Doppler echocardiography Ventricular Function Left law.invention Coronary artery bypass surgery law Heart Rate Internal medicine medicine Cardiopulmonary bypass Image Processing Computer-Assisted Humans Cardiac Output Coronary Artery Bypass Myocardial Stunning Ejection fraction Cardiopulmonary Bypass medicine.diagnostic_test business.industry Stroke Volume Stroke volume Myocardial Contraction Echocardiography Doppler surgical procedures operative Anesthesiology and Pain Medicine Echocardiography Anesthesia Cardiology Mitral Valve Female business Echocardiography Transesophageal circulatory and respiratory physiology |
| Zdroj: | Anesthesia and analgesia. 81(2) |
| ISSN: | 0003-2999 |
| Popis: | We investigated the effects of nitrous oxide (N 2 O) on central hemodynamics and left ventricular systolic and diastolic function in 25 patients undergoing coronary artery bypass surgery. All patients were receiving β-blockers and had good left ventricular function. Global and regional systolic left ventricular performance and diastolic function were determined by computer-assisted analysis of transesophageal echocardiographic (TEE) images, and mitral Doppler flow profiles, respectively. The patients were anesthetized with fentanyl and ventilated with oxygen in air. Hemodynamic and TEE measurements were obtained before and after the introduction of N 2 O in oxygen (60%/40%), before and after cardiopulmonary bypass (CPB). N 2 O reduced mean arterial pressure, heart rate, stroke volume, and cardiac output both before and after CPB. Left ventricular global area ejection fraction (GAEF) was not changed by the introduction of N 2 O, either before or after CPB. N 2 O induced a significant change in regional wall motion after, but not before CPB, as assessed by the relationship between segmental area ejection fraction (SAEF) and GAEF. Analysis of the mitral flow profile indicated an increase in early diastolic relaxation in the pre-CPB period after introduction of N 2 O, that was absent in the post-CPB period. We conclude that N 2 O induces regional wall motion abnormalities and possibly diastolic dysfunction post-CPB. (Anesth Analg 1995 ;81 :243-8) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|