Glucagon regulates its own synthesis by autocrine signaling
| Autor: | Ingo B. Leibiger, Tilo Moede, Daniel Kaiser, Barbara Leibiger, Thusitha P. Muhandiramlage, Per Olof Berggren, Pilar Vaca Sanchez |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
030209 endocrinology & metabolism Biology Autocrine Communication Glucagon Mice 03 medical and health sciences 0302 clinical medicine Receptors Glucagon Animals Humans Insulin Peptide hormone secretion RNA Messenger Autocrine signalling Protein Kinase C Glucagon-like peptide 1 receptor 030304 developmental biology 0303 health sciences Multidisciplinary Biological Sciences Cyclic AMP-Dependent Protein Kinases Hormones Gene Expression Regulation Biochemistry Hormone receptor Peptides Glucagon receptor Glucagon receptor family Protein Binding Signal Transduction |
| Zdroj: | Proceedings of the National Academy of Sciences. 109:20925-20930 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1212870110 |
| Popis: | Peptide hormones are powerful regulators of various biological processes. To guarantee continuous availability and function, peptide hormone secretion must be tightly coupled to its biosynthesis. A simple but efficient way to provide such regulation is through an autocrine feedback mechanism in which the secreted hormone is “sensed” by its respective receptor and initiates synthesis at the level of transcription and/or translation. Such a secretion–biosynthesis coupling has been demonstrated for insulin; however, because of insulin’s unique role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exception rather than a more generally used mechanism. Here we provide evidence of a secretion–biosynthesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels. We show that glucagon, secreted by the pancreatic α cell, up-regulates the expression of its own gene by signaling through the glucagon receptor, PKC, and PKA, supporting the more general applicability of an autocrine feedback mechanism in regulation of peptide hormone synthesis. |
| Databáze: | OpenAIRE |
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