EVALUATION OF PHAGOCYTIC-ACTIVITY IN NEOPLASTIC PATIENTS TREATED WITH SUBCUTANEOUS RECOMBINANT IL-2

Autor:	M Cattedra, C. D. Dragone, A Casamassima, M Guida, M Musci, M. Correale, L Addabbo, M Delena, A Latorre, I Abbate
Rok vydání:	1993
Předmět:	Cancer Research Beta-2 microglobulin Monocyte Phagocytosis Neopterin hemic and immune systems chemical and pharmacologic phenomena Granulocyte Biology Complement system chemistry.chemical_compound Immune system medicine.anatomical_structure Oncology chemistry Immunology medicine Macrophage
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.3.4.603
Popis:	Immunostimulating and immunosuppresive events have been noted during rIL-2 immunotherapy and cell-mediated immune deficiencies have been reported in the neutrophil and monocyte functions, determining a high incidence of infections in patients during intravenous rIL-2 treatment. The phagocytic activity of monocytes/macrophages and granulocytes was evaluated in 10 advanced solid tumor patients treated with subcutaneous rIL-2. Several indirect parameters of phagocytosis were also considered, such as Neopterin, Beta2 microglobulin, IL-2 soluble receptor, and the C3 and C4 fractions of the complement system. A decreased phagocytosis was demonstrated after subcutaneous rIL-2 administration together with an increase of indirect parameters of granulocyte/macrophage activity. Therefore, cellular activation does not seem to correspond to actual phagocytosis which is probably due to IL-2-induced secondary cytokines or to rIL-2 inhibitory effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edec19bea5d4976ccd9d83e49d94012 https://doi.org/10.3892/ijo.3.4.603 Zobrazit plný text záznamu