Hypercoagulopathy in Stroke Patients with Nonvalvular Atrial Fibrillation: Hematologic and Cardiologic Investigations
| Autor: | Ufuk Utku, Gültaç Özbay, Nilda Turgut, Burhan Turgut, Muzaffer Demir, Osman Akdemir, Özden Vural, Galip Ekuklu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030204 cardiovascular system & hematology Fibrinogen Thrombophilia Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Internal medicine Atrial Fibrillation Severity of illness medicine Humans Sinus rhythm cardiovascular diseases Stroke Aged medicine.diagnostic_test business.industry Cerebral infarction Atrial fibrillation Hematology General Medicine Middle Aged medicine.disease Peptide Fragments 030104 developmental biology Case-Control Studies Cardiology Drug Evaluation Female Prothrombin business Electrocardiography medicine.drug |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 12:15-20 |
| ISSN: | 1938-2723 1076-0296 |
| DOI: | 10.1177/107602960601200104 |
| Popis: | The coagulation system is activated and coagulation activation markers are elevated in acute ischemic stroke with nonvalvular atrial fibrillation (NVAF). The etiology, severity, and prognosis of the ischemic stroke might be estimated with the level of the activation of the coagulation system. In this study, prothrombin F1+2 (F1+2), D-dimer, and fibrinogen levels were measured in patients with acute ischemic stroke with and without NVAF, and stroke severity was compared with these hemostatic parameters. Of 55 patients, 29 had sinus rhythm (group I), 26 had NVAF (group II); 20 healthy subjects (group III) were included in the study. Subtypes of cerebral infarction were classified. The patients underwent stroke severity, electrocardiography, echocardiography, cranial computed tomography, cervical duplex ultrasonography, and hemostatic parameter studies. In group II, F1+2 level (2.83±0.89) was significantly higher than in group I (2.33±0.80) and III (1.94±0.64) (p values: group I-II, 0.036; groups II-III, 0.001; groups I-III, 0.104). In group III, fibrinogen level (251.64±60.96) was significantly lower than that in groups I (347.97±111.49) and II (364.04±86.20) (p=0.001). D-dimer was not significantly different between groups. In group I, lacunar syndrome (LACS), and in group II, partial and total anterior circulation syndrome (PACS+TACS) were more common (p=0.013, p=0.001, respectively). In group II, Scandinavian Stroke Scale scores were lower than those in group I (group I=45.2±14, group II=35.4±18.9, p=0.02). In conclusion, activation of coagulation, demonstrated by increment F1+2, is more abundant in the stroke patients with NVAF than in the stroke patients with sinus rhythm. Our results also showed that activation of the hemostatic system might be related to stroke subtype and stroke severity. It is suggested that the oral anticoagulation treatment as prophylaxis is important in the prevention of stroke in patients with NVAF. |
| Databáze: | OpenAIRE |
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