Chemotyping of ∆8-THC-Containing e-Liquids Analyzed during the 2019–2020 New York State EVALI Investigation
| Autor: | David C. Spink, Lorie A. Durocher, E M Delaney-Baldwin, Shijun Lu, Mark A Dittmar, Lingyun Li, Bryan C. Duffy |
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| Rok vydání: | 2021 |
| Předmět: |
Chemical Health and Safety
biology Cannabinoids Chemistry Vaping organic chemicals Health Toxicology and Mutagenesis medicine.medical_treatment New York Electronic Nicotine Delivery Systems Lung injury Toxicology biology.organism_classification Analytical Chemistry mental disorders Hallucinogens medicine Environmental Chemistry Dronabinol Cannabinoid Food science Cannabis Manufacturing methods Cannabidiol medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 46:743-749 |
| ISSN: | 1945-2403 0146-4760 |
| Popis: | The investigation of the 2019–2020 E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) outbreak in New York State provided a unique opportunity to examine the formulations and chemical components found in clandestine cannabis-containing e-liquids. In this EVALI investigation, it was determined that an unusually high proportion (16%) of the cannabis e-liquids analyzed contained significant levels of ∆8-tetrahydrocannabinol (∆8-THC). Although not thought to be the causative agent in the outbreak, the manufacturing origin of vaping e-liquids containing large concentrations of ∆8-THC was of great interest, since high ∆8-THC concentrations are not observed in the extracts of common cannabis strains. A principal component analysis of multiple cannabinoid concentrations revealed clusters of similar or identical ∆8-THC-containing products. This technique may be useful in identifying common manufacturing sources in this and future investigations. Several possible manufacturing methods to enrich ∆8-THC appear in literature and are discussed based on their likelihood as sources of this cannabinoid in these samples from the EVALI investigation. The presence of high levels of ∆8-THC in numerous illicit vaping products may implicate cannabidiol, which is readily available at low cost, as its synthetic precursor. |
| Databáze: | OpenAIRE |
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