A Comparison of levobupivacaine 0.5% and racemic bupivacaine 0.5% for extradural anesthesia for caesarean section
| Autor: | Kathryne A. Faccenda, Elizabeth M. McGrady, Drew Smith, Lachlan M. M. Morrison, D. J. Henderson, Alison M. Simpson |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Anesthesia Epidural medicine.medical_specialty Time Factors Adolescent medicine.drug_class medicine.medical_treatment Pain Racemic bupivacaine Double-Blind Method Pregnancy medicine Anesthesia Obstetrical Humans Potency Caesarean section Anesthetics Local Levobupivacaine Bupivacaine Cesarean Section Local anesthetic business.industry Infant Newborn Stereoisomerism General Medicine Surgery Treatment Outcome Anesthesiology and Pain Medicine Elective Surgical Procedures Anesthesia Apgar Score Female Apgar score Elective Surgical Procedure business medicine.drug |
| Zdroj: | Regional Anesthesia and Pain Medicine. 28:394-400 |
| ISSN: | 1098-7339 |
| DOI: | 10.1016/s1098-7339(03)00223-2 |
| Popis: | Background and Objectives: Bupivacaine is available as a racemic mixture of its enantiomers, dextrobupivacaine and levobupivacaine. Both in vitro and in vivo studies show that dextrobupivacaine has a greater inherent central nervous system (CNS) and cardiovascular toxicity than levobupivacaine. Clinical studies show levobupivacaine to have similar local anesthetic potency to the racemate. The aim of this study was to investigate the clinical efficacy and safety of levobupivacaine compared with racemic bupivacaine for extradural anesthesia. Methods: We studied 62 patients undergoing elective caesarean delivery who received 25 mL of either levobupivacaine 0.5% or bupivacaine 0.5%, extradurally, in a randomized, double-blind study. Results: The 2 groups were similar in terms of time to block suitable for surgery, segmental spread, and duration of sensory block. However, lower-limb motor block was significantly longer in the levobupivacaine group but of significantly less intensity. Conclusions: Levobupivacaine produces an extradural block that is similar to bupivacaine, and is a suitable local anesthetic agent for caesarean delivery. |
| Databáze: | OpenAIRE |
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