Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
| Autor: | Gaëlle Pierron, Andrew D.J. Pearson, B. De Bernardi, Ruth Ladenstein, Nathalie Auger, Gian Paolo Tonini, Mary Gerrard, Combaret, Bárbara Marques, K Wheeler, Klaus Beiske, A F de Lacerda, Jérôme Couturier, Olivier Delattre, Jean Bénard, Deborah A. Tweddle, Gudrun Schleiermacher, Bénédicte Brichard, Agnès Ribeiro, Hervé Rubie, Rosa Noguera, I.M. Ambros, Castel, Mosseri, Katia Mazzocco, Nick Bown, Adela Cañete, R. Defferrari, Caroline Munzer, Peter F. Ambros, Jean Michon, Isabelle Janoueix-Lerosey, A. Di Cataldo, Eva Villamón, N. Van Roy |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Chromosomal Alterations N-Myc Proto-Oncogene Protein segmental chromosome alterations neuroblastoma Neuroblastoma Recurrence Internal medicine medicine Humans Prospective Studies Stage (cooking) Relapse risk Prospective cohort study genomic profile Survival analysis Chromosome Aberrations Oncogene Proteins infants business.industry Infant Nuclear Proteins Genetics and Genomics Prognosis medicine.disease Survival Analysis Doenças Genéticas Segmental Chromosome Alterations High Risk Genomic Profile business |
| Zdroj: | British Journal of Cancer BRITISH JOURNAL OF CANCER r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2011.472 |
| Popis: | BACKGROUND: In neuroblastoma (NB), the presence of segmental chromosome alterations (SCAs) is associated with a higher risk of relapse. METHODS: In order to analyse the role of SCAs in infants with localised unresectable/disseminated NB without MYCN amplification, we have performed an array CGH analysis of tumours from infants enrolled in the prospective European INES trials. RESULTS: Tumour samples from 218 out of 300 enroled patients could be analysed. Segmental chromosome alterations were observed in 11%, 20% and 59% of infants enroled in trials INES99.1 (localised unresectable NB), INES99.2 (stage 4s) and INES99.3 (stage 4) (P |
| Databáze: | OpenAIRE |
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