Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity
Autor: | Courtney E. McDougal, John-Demian Sauer |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Microbiology (medical) Programmed cell death lcsh:Medicine Review Biology medicine.disease_cause Microbiology necrosis 03 medical and health sciences Immune system Listeria monocytogenes Immunity medicine Immunology and Allergy cell-mediated immunity Molecular Biology 030102 biochemistry & molecular biology General Immunology and Microbiology Intracellular parasite pyroptosis lcsh:R Pyroptosis apoptosis CD8+ T-cells Acquired immune system 030104 developmental biology Infectious Diseases cell death Intracellular |
Zdroj: | Pathogens, Vol 7, Iss 1, p 8 (2018) Pathogens |
ISSN: | 2076-0817 |
Popis: | Listeria monocytogenes has evolved exquisite mechanisms for invading host cells and spreading from cell-to-cell to ensure maintenance of its intracellular lifecycle. As such, it is not surprising that loss of the intracellular replication niche through induction of host cell death has significant implications on the development of disease and the subsequent immune response. Although L. monocytogenes can activate multiple pathways of host cell death, including necrosis, apoptosis, and pyroptosis, like most intracellular pathogens L. monocytogenes has evolved a series of adaptations that minimize host cell death to promote its virulence. Understanding how L. monocytogenes modulates cell death during infection could lead to novel therapeutic approaches. In addition, as L. monocytogenes is currently being developed as a tumor immunotherapy platform, understanding how cell death pathways influence the priming and quality of cell-mediated immunity is critical. This review will focus on the mechanisms by which L. monocytogenes modulates cell death, as well as the implications of cell death on acute infection and the generation of adaptive immunity. |
Databáze: | OpenAIRE |
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