Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone–Tendon Healing: A Rabbit Animal Model

Autor: Chih-Yu Chen, Feng-Huei Lin, Chih Chieh Huang, Hsin Hsin Shen, Yu Min Huang, Hong Jen Lai, Shu Wei Huang, San-Yuan Chen, Shin I. Huang, Pei I. Tsai, Kuo Yi Yang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Calcium Phosphates
Anterior cruciate ligament reconstruction
medicine.medical_treatment
Bone Screws
02 engineering and technology
Tendons
lcsh:Chemistry
0302 clinical medicine
titanium-alloy implant
Tendon healing
lcsh:QH301-705.5
Spectroscopy
030222 orthopedics
Rabbit (nuclear engineering)
General Medicine
021001 nanoscience & nanotechnology
musculoskeletal system
Computer Science Applications
Tendon
medicine.anatomical_structure
surgical procedures
operative
Printing
Three-Dimensional
Rabbits
0210 nano-technology
Porosity
additive manufacturing
Titanium
musculoskeletal diseases
Materials science
Simulated body fluid
chemistry.chemical_element
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
bioactive ceramic coating
Osseointegration
Bone-Implant Interface
medicine
Alloys
Animals
Physical and Theoretical Chemistry
Molecular Biology
Tibia
Organic Chemistry
Titanium alloy
equipment and supplies
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Surface modification
interference screw
Biomedical engineering
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 3628, p 3628 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
ISSN: 1661-6596
1422-0067
Popis: The interference screw fixation method is used to secure a graft in the tibial tunnel during anterior cruciate ligament reconstruction surgery. However, several complications have been reported, such as biodegradable screw breakage, inflammatory or foreign body reaction, tunnel enlargement, and delayed graft healing. Using additive manufacturing (AM) technology, we developed a titanium alloy (Ti6Al4V) interference screw with chemically calcium phosphate surface modification technology to improve bone integration in the tibial tunnel. After chemical and heat treatment, the titanium screw formed a dense apatite layer on the metal surface in simulated body fluid. Twenty-seven New Zealand white rabbits were randomly divided into control and additive manufactured (AMD) screw groups. The long digital extensor tendon was detached and translated into a tibial plateau tunnel (diameter: 2.0 mm) and transfixed with an interference screw while the paw was in dorsiflexion. Biomechanical analyses, histological analyses, and an imaging study were performed at 1, 3, and 6 months. The biomechanical test showed that the ultimate pull-out load failure was significantly higher in the AMD screw group in all tested periods. Micro-computed tomography analyses revealed early woven bone formation in the AMD screw group at 1 and 3 months. In conclusion, AMD screws with bioactive surface modification improved bone ingrowth and enhanced biomechanical performance in a rabbit model.
Databáze: OpenAIRE
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