Endometrial leukocyte subpopulations in women with endometriosis
| Autor: | Judith N. Bulmer, Lynn Morrison, Lucas D. Klentzeris, D.T. Liu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Stromal cell media_common.quotation_subject Biopsy T-Lymphocytes Endometriosis Luteal phase CD38 Endometrium Immunophenotyping Andrology Internal medicine medicine Leukocytes Humans Lymphocytes Menstrual cycle media_common B-Lymphocytes medicine.diagnostic_test business.industry Macrophages Obstetrics and Gynecology Antibodies Monoclonal medicine.disease Immunohistochemistry Killer Cells Natural medicine.anatomical_structure Endocrinology Lymphatic system Reproductive Medicine Female business Infertility Female |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 63(1) |
| ISSN: | 0301-2115 |
| Popis: | The aim of this study was to investigate whether the endometrium of women with endometriosis differs immunologically from the endometrium of normal fertile women. Endometrial biopsies were obtained from 18 normal fertile women who were requesting sterilisation or reversal of sterilisation and 21 infertile women who had laparoscopically diagnosed pelvic endometriosis. The endometrial biopsies were obtained from both groups during the either early, mid or late luteal phase of the menstrual cycle. A panel of 11 monoclonal antibodies and immuno-histochemical techniques were employed to characterise the endometrial stromal leukocytes in frozen sections. Image analysis was used for semi quantitation of leukocytes. In both groups, the number of endometrial granulated lymphocytes (CD56 + CD38 + cells) and macrophages (CD68 + cells) increased significantly between the early and late luteal phase of the menstrual cycle. Compared with fertile controls, women with endometriosis had fewer T-suppressor/cytotoxic (CD8 +) cells and endometrial granulated lymphocytes but more T-helper/inducer (CD4 +) cells, CD68 + cells and CD16 + cells. None of these differences reached a statistically significant level. This study has shown that the endometrial lymphoid tissue of women with endometriosis does not differ qualitatively or quantitively from that of normal fertile controls. However, functional differences of endometrial leukocytes between the two groups cannot be excluded. |
| Databáze: | OpenAIRE |
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