Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey
| Autor: | Manuel Víctor López-González, Marc Stefan Dawid-Milner, Miguel Ángel Barbancho, Carlos Antonio Peinado-Aragonés, Amelia Díaz-Casares, Marta González-García |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Tachycardia medicine.medical_specialty Respiratory rate Physiology Pontine Tegmentum 030209 endocrinology & metabolism Stimulation Biochemistry Rats Sprague-Dawley Midbrain 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mesencephalon Internal medicine Extracellular medicine Animals Periaqueductal Gray Neurons business.industry General Medicine Electric Stimulation Rats 030104 developmental biology Endocrinology Muscimol chemistry Hypertension Microinjections Breathing medicine.symptom business |
| Zdroj: | Journal of Physiology and Biochemistry. 76:561-572 |
| ISSN: | 1877-8755 1138-7548 |
| DOI: | 10.1007/s13105-020-00761-1 |
| Popis: | Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathing anesthetized rats. dlPAG was electrically stimulated (20–30 μA 1-ms pulses were given for 5 s at 100 Hz). Changes in the evoked cardiorespiratoy response were analysed before and after ipsilateral microinjections of muscimol (GABAergic agonist, 50 nl, 0.25 nmol, 5 s) within the A5 region. Electrical stimulation of the dlPAG produces, in the rat, a response characterized by tachypnoea (p |
| Databáze: | OpenAIRE |
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