Risk-based approach to developing a national residue sampling plan for testing under European Union regulation for veterinary medicinal products and coccidiostat feed additives in domestic animal production
| Autor: | Dan O’Sullivan, Francis Butler, Peadar G. Lawlor, Rhodri Evans, D Glynn, Tim Camon, Michael O'Keeffe, Martin Danaher, Conor Shanahan |
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| Rok vydání: | 2016 |
| Předmět: |
Veterinary medicine
Coccidiostat Antifungal Agents Food Safety Meat Animal feed Swine Health Toxicology and Mutagenesis Antiprotozoal Agents Narasin Beef cattle Biology Toxicology 01 natural sciences Risk Assessment chemistry.chemical_compound Animal science Toltrazuril media_common.cataloged_instance Animals European Union European union Dairy cattle media_common Anthelmintics No-Observed-Adverse-Effect Level Sheep Goats 010401 analytical chemistry 0402 animal and dairy science Public Health Environmental and Occupational Health Veterinary Drugs 04 agricultural and veterinary sciences General Chemistry General Medicine 040201 dairy & animal science Animal Feed Drug Residues 0104 chemical sciences Anti-Bacterial Agents chemistry Nicarbazin Dietary Supplements Coccidiostats Cattle Chickens Food Science |
| DOI: | 10.6084/m9.figshare.3422650 |
| Popis: | A ranking system for veterinary medicinal products and coccidiostat feed additives has been developed as a tool to be applied in a risk-based approach to the residue testing programme for foods of animal origin in the Irish National Residue Control Plan (NRCP). Three characteristics of substances that may occur as residues in food are included in the developed risk ranking system: Potency, as measured by the acceptable daily intake assigned by the European Medicines Agency Committee for Medicinal Products for Veterinary Use, to each substance; Usage, as measured by the three factors of Number of Doses, use on Individual animals or for Group treatment, and Withdrawal Period; and Residue Occurrence, as measured by the number of Non-Compliant Samples in the NRCP. For both Number of Doses and Non-Compliant Samples, data for the 5-year period 2008-12 have been used. The risk ranking system for substances was developed for beef cattle, sheep and goats, pigs, chickens and dairy cattle using a scoring system applied to the various parameters described above to give an overall score based on the following equation: Potency × Usage (Number of Doses + Individual/Group Use + Withdrawal Period) × Residue Occurrence. Applying this risk ranking system, the following substances are ranked very highly: antimicrobials such as amoxicillin (for all species except pigs), marbofloxacillin (for beef cattle), oxytetracycline (for all species except chickens), sulfadiazine with trimethoprim (for pigs and chickens) and tilmicosin (for chickens); antiparasitic drugs, such as the benzimidazoles triclabendazole (for beef and dairy cattle), fenbendazole/oxfendazole (for sheep/goats and dairy cattle) and albendazole (for dairy cattle), the avermectin ivermectin (for beef cattle), and anti-fluke drugs closantel and rafoxanide (for sheep/goats); the anticoccidials monensin, narasin, nicarbazin and toltrazuril (for chickens). The risk ranking system described is a relatively simple system designed to provide a reliable basis for selecting the veterinary medicinal products and coccidiostat feed additives that might be prioritised for residue testing. |
| Databáze: | OpenAIRE |
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