Treatment outcomes among tuberculosis patients in Jeddah, Saudi Arabia: Results of a community mobile outreach directly observed Treatment, Short-course (DOTS) project, compared to a standard facility-based DOTS: A randomized controlled trial
| Autor: | Fatima Al-Garni, Mahmoud Madani Alali, Najlaa Mandoura, Abdullah Al-Garni, Mohammed F. Buksh, Abdulhamed L. Moawwad, Muhammad Assiri, Ola A. Abdul-Rashid, Abdulrahim I.A. Almalki, Hassan Bin Usman Shah, Khalid Al Sharif, Mashal Mesfer Al-Sayali, Maha Alawi, Abdullah Y. Alzahrani, Maataug M. Al-Osaimi, Emad Lafi Almohammadi, Alaa Khalawi, Abdullah J Al-Sahafi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis Success 030106 microbiology Developing country Article lcsh:Infectious and parasitic diseases law.invention Short-course (DOTS) 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Intervention (counseling) Medicine lcsh:RC109-216 Short course 030212 general & internal medicine Treatment outcome lcsh:RC705-779 Directly observed treatment Community outreach business.industry Public health Default Mobile outreach teams lcsh:Diseases of the respiratory system medicine.disease Outreach Impact Infectious Diseases Relative risk Family medicine business |
| Zdroj: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 22, Iss, Pp 100210-(2021) Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| ISSN: | 2405-5794 |
| DOI: | 10.1016/j.jctube.2020.100210 |
| Popis: | Introduction: Tuberculosis (TB) remains a global public health threat affecting people in many developing countries, including the Kingdom of Saudi Arabia. Maintaining a long-term treatment regimen has always been the cornerstone of successful treatment outcomes among tuberculosis patients. In the Jeddah region, the National Tuberculosis Control and Prevention Program is now treating TB patients by means of a community mobile outreach team approach.The objective of this study was to compare the effectiveness of the community mobile outreach approach in improving treatment outcomes (success rate) among local tuberculosis patients with those being treated with a facility-based directly observed treatment, short-course (DOTS). Study design: Our study consisted of a two-sample, parallel design [1:1], statistician -blind randomized control trial with 200 newly diagnosed, TB patients as subjects. Setting/participants: The patients had all presented at the Madain Alfahd Primary Health Care Center, Jeddah. Between Nov 2017 and Nov 2018, a total of 221 TB patients were screened of whom 200 were randomly selected using randomly generated sequences. Intervention: Patients in the intervention sample group were treated by means of mobile outreach teams with oral anti-TB treatment under the DOTS, and control group patients were given the traditional facility-based DOTS treatment according to the WHO recommendations and national guidelines. Main outcome: The primary outcome was the level of overall treatment success rate. It was finally determined and compared in the two sample groups using chi-square analysis and relative risk assessment. Results: In the analysis stage, 97 patients were in the intervention group, while the control group consisted of 76. The overall response rate was 86.5% (173/200). We found that the percentage of overall treatment success rate among the patients served by the mobile outreach team was 97%, compared to 76% in the non-mobile team treated patients. The relative risk of treatment success rate among the intervention group was 1.27 (95% CI = 1.13–1.43) times greater than that amongst the control group. Log-rank test (log-rank statistics = 18.91; p |
| Databáze: | OpenAIRE |
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