Phylogenetic analysis of Alphapapillomavirus based on L1, E6 and E7 regions suggests that carcinogenicity and tissue tropism have appeared multiple times during viral evolution
| Autor: | Alexis Rojas-Cruz, Alejandro Reyes-Bermúdez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) food.ingredient Genotype Papillomavirus E7 Proteins 030106 microbiology Virulence Uterine Cervical Neoplasms Alphapapillomavirus Biology Microbiology Evolution Molecular 03 medical and health sciences Monophyly food Genetics Humans Amino Acid Sequence Molecular Biology Gene Ecology Evolution Behavior and Systematics Conserved Sequence Phylogeny Phylogenetic tree Base Sequence Computational Biology Oncogene Proteins Viral Cell Transformation Viral Viral Tropism 030104 developmental biology Infectious Diseases Viral evolution Mutation Tissue tropism Female Adaptation |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 67 |
| ISSN: | 1567-7257 |
| Popis: | Members of the Alphapapillomavirus genus are causative agents for cervix cancer and benign lesions in humans. These viruses are classified according to sequence similarities in their L1 region. Yet, viral carcinogenicity has been associated with variations in the proteins encoded by the E6 and E7 genes. In order to relate evolutionary history with origin of carcinogenicity, we performed phylogenetic reconstructions using both nucleotide and predicted amino acid sequences of the L1, E6 and E7 genes. Whilst phylogenetic analysis of L1 reconstructed genus evolutionary history, phylogenies based on E6 and E7 proteins support the idea that mutations at amino acids S/Tx [V/L] (E6) and LxCxE (E7) might be responsible for carcinogenic potential. These findings indicate that virulence within Alphapapillomavirus have appeared multiple times during evolution. Our results reveal that oncogenic potential is not a monophyletic clade-specific adaptation but might be the result of positive selection on random mutations occurring on proteins involved in host infection during viral diversification. |
| Databáze: | OpenAIRE |
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