A solution to the cyclic aldol problem
| Autor: | Daniel C. Weinseimer, Steven W. Baldwin, Ping Chen, Nikola Nikolic |
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| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | Organic letters. 2(9) |
| ISSN: | 1523-7052 |
| Popis: | [formula: see text] A protocol for achieving stereoselective aldol reactions with cyclic ketones is presented. In terms of yield, the process is particularly effective when a quaternary center at the alpha-carbon of the beta-hydroxy ketone product is created. The stereochemical outcome, anti or syn, is achieved by the Lewis acid-mediated ring expansion of stereochemically homogeneous epoxides in a reaction related to the pinacol rearrangement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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