Transcriptional Activation by Nur77, a Growth Factor-lnducible Member of the Steroid Hormone Receptor Superfamily
| Autor: | Thomas G. Hazel, Lester F. Lau, Ian J. Davis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chloramphenicol O-Acetyltransferase
Transcriptional Activation Receptors Steroid Transcription Genetic Nerve growth factor IB Steroid hormone receptor medicine.medical_treatment Receptors Cytoplasmic and Nuclear Biology Transfection Cell Line Endocrinology Nuclear Receptor Subfamily 4 Group A Member 1 medicine Animals Molecular Biology Transcription factor Hormone response element Thyroid hormone receptor Chimera Growth factor General Medicine TCF4 beta-Galactosidase Molecular biology Cell biology DNA-Binding Proteins Gene Expression Regulation Multigene Family Transcription Coactivator Plasmids Transcription Factors |
| Zdroj: | Molecular Endocrinology. 5:854-859 |
| ISSN: | 1944-9917 0888-8809 |
| Popis: | nur77 is a growth factor-inducible immediate early gene that encodes a protein with extensive sequence homology to members of the steroid/thyroid hormone receptor superfamily. By analogy to steroid receptors, the Nur77 protein is thought to act as a ligand-dependent transcription factor that regulates the genomic response to growth factors. Using chimeric gene constructs, we show that Nur77 can indeed function as a transcription activator. Furthermore, Nur77 chimeras can activate transcription in the absence of an exogenously added ligand. |
| Databáze: | OpenAIRE |
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