Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache
| Autor: | Zhong Zheng, Won Kim, Claire D. Clelland, Ausaf A. Bari, Nader Pouratian |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cerebellum Deep brain stimulation Cluster headache cerebellum Nerve net Deep Brain Stimulation medicine.medical_treatment Clinical Sciences Treatment outcome Hypothalamus Cluster Headache Bioengineering Sensitivity and Specificity Probabilistic tractography Clinical Research Neural Pathways Connectome medicine Humans Assistive Technology Neurology & Neurosurgery Headaches business.industry Rehabilitation Pain Research Neurosciences Reproducibility of Results General Medicine Middle Aged medicine.disease Brain Disorders probabilistic tractography Treatment Outcome Diffusion Tensor Imaging medicine.anatomical_structure nervous system Neurological Female Neurology (clinical) Nerve Net business Neuroscience |
| Zdroj: | Cephalalgia : an international journal of headache, vol 34, iss 3 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1177/0333102413509431 |
| Popis: | Background Several centers have reported efficacious cluster headache suppression with deep brain stimulation (DBS) of the hypothalamic region using a variety of targets. While the connectivity of some of these targets has individually been studied, commonalities across these targets, especially with respect to network-level connectivity, have not previously been explored. Methods We examined the anatomic connectivity of the four distinct DBS targets reported in the literature using probabilistic diffusion tensor tractography in normal subjects. Results Despite being described as hypothalamic, the DBS targets localized in the midbrain tegmentum posterior to the hypothalamus. Common tracts across DBS targets and subjects included projections to the ipsilateral hypothalamus, reticular formation, and cerebellum. Discussion Although DBS target coordinates are not located within the hypothalamus, a strong connection between DBS targets and the hypothalamus likely exists. Moreover, a common projection to the medial ipsilateral cerebellum was identified. Understanding the common connectivity of DBS-targeted regions may elucidate anatomic pathways that are involved in modulating cluster headache attacks and facilitate more precise patient-specific targeting of DBS. |
| Databáze: | OpenAIRE |
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