Is procalcitonin a marker of critical illness in heatstroke?
| Autor: | Virginie Lvovschi, Sylvie Chollet-Martin, O. Lidove, Margarita Hurtado, Maguy Bernard, Gaëlle Juillien, Pierre Hausfater, Sepehr Salehabadi, Michel Wolff, Sebastian Pease, Bruno Riou |
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| Rok vydání: | 2008 |
| Předmět: |
Calcitonin
Male Paris congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty genetic structures Calcitonin Gene-Related Peptide Heat Stroke Poison control Comorbidity Critical Care and Intensive Care Medicine Gastroenterology Procalcitonin law.invention Cohort Studies law Intensive care Internal medicine parasitic diseases medicine Humans Protein Precursors Intensive care medicine Hospital ward Aged business.industry Extreme Heat Heatstroke Middle Aged Prognosis bacterial infections and mycoses medicine.disease Intensive care unit Intensive Care Units Multicenter study Critical illness Female Emergency Service Hospital business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Intensive Care Medicine. 34:1377-1383 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s00134-008-1083-y |
| Popis: | To study the effect of non-exertional heatstroke on serum procalcitonin (PCT) levels.Cohort study.The emergency and intensive care departments of two academic tertiary-care hospitals, Paris, FranceA total of 53 patients with defined heatstroke attending the emergency department and/or the intensive care unit during the August 2003 heat wave in France.None.Serum PCT measurement using a sensitive assay and vital and routine biological variables on arrival of patients presenting with classic heatstroke. Thirty-day mortality was recorded.Among the 53 patients included, 14 (26%) were admitted to an intensive care unit (ICU). At 30 days, 24 patients (45%) had died. Median PCT value was 0.58 microg/l (95% confidence interval 0.16-1.61) and 31 (58%) patients had PCT above 0.2 microg/l (PCT+). Temperature above or equal to 40 degrees C was the only variable significantly associated with fatal outcome. Median PCT values were 1.4 microg/l (0.16-4.71) and 0.18 microg/l (0.12-1.61) in the group of deceased and surviving patients respectively (p = 0.22). All patients admitted in ICU had elevated PCT values. Patients PCT+ initially presented with a more pronounced systemic inflammatory response. Microbiologically or clinically documented infection was not more frequent in PCT+ group.High serum PCT levels can be observed in heatstroke without any concomitant documented bacterial infection. The PCT is not a valid mortality predictor in heatstroke but could be an indicator of the severity of illness. Heatstroke could represent a model of a "non-septic" pathway of PCT synthesis. |
| Databáze: | OpenAIRE |
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