Effect of colchicine in prevention of pericardial effusion and atrial fibrillation: a meta-analysis
| Autor: | Qian Wang, Ming-xuan Wang, Xiao-long Deng, Ci-bo Huang, Bingyao Mu, Rongwei Zhou, Yingjuan Chen, Yongjing Cheng, Jia Huang |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Lower risk Pericardial effusion Pericardial Effusion 03 medical and health sciences chemistry.chemical_compound Pericarditis 0302 clinical medicine Recurrence Internal medicine Cardiac tamponade Atrial Fibrillation Internal Medicine medicine Humans Colchicine 030212 general & internal medicine Cardiac Surgical Procedures Adverse effect Chi-Square Distribution business.industry Atrial fibrillation medicine.disease Cardiac surgery chemistry Emergency Medicine Cardiology business |
| Zdroj: | Internal and Emergency Medicine. 11:867-876 |
| ISSN: | 1970-9366 1828-0447 |
| DOI: | 10.1007/s11739-016-1496-5 |
| Popis: | Randomized, controlled trials (RCTs) have assessed the effect of colchicine therapy in prevention of pericardial effusion (PE) and atrial fibrillation (AF). However, the effects are still inconclusive. PubMed, Cochrane Library, Google Scholar, and EMBASE database were searched. Primary outcome was the risk of PE and AF. Ten RCTs with 1981 patients and a mean follow-up of 12.6 months were included. Colchicine therapy was not associated with a significantly lower risk of post-operative PE (RR, 0.89; 95 % CI 0.70-1.13; p = 0.33, I (2) = 72.8 %) and AF (RR, 0.77; 95 % CI 0.52-1.13; p = 0.18, I (2) = 47.3 %). However, rates of pericarditis recurrence, symptoms persistence, and pericarditis-related hospitalization were significantly decreased with colchicine treatment. In addition, cardiac tamponade occurrence was similar between groups, and adverse events were significantly higher in the colchicine group. Colchicine may not significantly decrease the post-operative risk of PE and AF. However, only limited studies about patients undergoing cardiac surgery provide data about PE and AF. |
| Databáze: | OpenAIRE |
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