Post-traumatic amnesia predicts long-term cerebral atrophy in traumatic brain injury
| Autor: | Erin D. Bigler, Claudia Pedroza, Elisabeth A. Wilde, David K. Ryser |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors Adolescent Psychometrics Traumatic brain injury Neuroscience (miscellaneous) Amnesia urologic and male genital diseases Cerebral Ventricles Neuroimaging otorhinolaryngologic diseases Developmental and Educational Psychology medicine Humans Cerebral atrophy Post-traumatic amnesia Brain Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging nervous system diseases Surgery surgical procedures operative Brain Injuries Anesthesia Chronic Disease Amnesia Retrograde Female Neurology (clinical) Atrophy medicine.symptom Psychology |
| Zdroj: | Brain Injury. 20:695-699 |
| ISSN: | 1362-301X 0269-9052 |
| DOI: | 10.1080/02699050600744079 |
| Popis: | To examine post-traumatic amnesia (PTA) and its relation to long-term cerebral atrophy in persons with traumatic brain injury (TBI) using objective indicators of PTA duration and Quantitative Magnetic Resonance Imaging (QMRI). It was hypothesized that longer PTA would predict later generalized atrophy (increased ventricle-to-brain ratio (VBR)). As a guide in assessing patients with TBI, this study determined the probability of developing chronic cerebral atrophy based on PTA duration.Probability model using 60 adult patients with mild-to-severe TBI.A logistic regression model with a cut-off determined by normative QMRI data confirmed that longer PTA duration predicts increased VBR. A probability model demonstrated a 6% increase in the odds of developing later atrophy on neuroimaging with each additional day of PTA.PTA has previously proven to be a good indicator of later cognitive recovery and functional outcome and also predicts long-term parenchymal change. |
| Databáze: | OpenAIRE |
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