Systemic inflammation and lung function in young adults
| Autor: | Avis Williamson, Christene R. McLachlan, D. Robin Taylor, Finn Rasmussen, Justina M. Greene, Robert J. Hancox, Michael J.A. Williams, Susan Filsell, Richie Poulton, Malcolm R. Sears |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Vital capacity Vital Capacity Systemic inflammation Cohort Studies Lung Function Internal medicine Forced Expiratory Volume medicine Humans Risk factor Bronchitis Asthma biology business.industry Respiratory disease C-reactive protein respiratory system medicine.disease respiratory tract diseases C-Reactive Protein Cross-Sectional Studies Immunology biology.protein Female medicine.symptom business Body mass index |
| Zdroj: | Thorax. 62(12) |
| ISSN: | 1468-3296 |
| Popis: | Background: Impaired lung function is associated with systemic inflammation and is a risk factor for cardiovascular disease in older adults. It is unknown when these associations emerge and to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between the forced expiratory volume in one second (FEV 1 ) and the systemic inflammatory marker C-reactive protein (CRP) in young adults. Methods: Associations between spirometric lung function and blood CRP were assessed in a population based birth cohort of approximately 1000 New Zealanders at ages 26 and 32 years. Analyses adjusted for height and sex to account for differences in predicted lung function and excluded pregnant women. Results: There were significant inverse associations between FEV 1 and CRP at both ages. Similar results were found for the forced vital capacity. These associations were similar in men and women and were independent of smoking, asthma, and body mass index. Conclusions: Reduced lung function is associated with systemic inflammation in young adults. This association is not related to smoking, asthma, or obesity. The reasons for the association are unexplained, but the findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis. The association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism. |
| Databáze: | OpenAIRE |
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