| Autor: |
Rena Buckstein, Lisa Chodirker, Karen W.L. Yee, Michelle Geddes, Heather A. Leitch, Grace Christou, Versha Banerji, Brian Leber, Dina Khalaf, Eve St-Hilaire, Nicholas Finn, Thomas Nevill, Mary-Margaret Keating, John Storring, Anne Parmentier, Aksharh Thambipillai, Derek Tang, Christopher Westcott, Chris Cameron, Paul Spin |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Leukemialymphoma. |
| ISSN: |
1029-2403 |
| Popis: |
Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC transfusions in LR MDS with ring sideroblasts (LR MDS-RS) are not well known. We estimated the association between cumulative RBC dose density and clinical and patient-reported outcomes using data from the MDS-CAN registry for patients enrolled between January 2008 and December 2018. Outcomes included overall survival, hospitalization, and health-related quality of life (HRQoL). A total of 145 enrolled patients with LR MDS and RS ≥5% had a median follow-up time of 27.1 months; 45 had no transfusions during follow-up, 51 had1 transfusion per month, and 49 had ≥1 transfusion per month. The cumulative density of RBC transfusions was associated with significantly greater mortality, hospitalization, and inferior HRQoL, suggesting that exposure to RBC transfusion may constitute a significant treatment burden in patients with LR MDS-RS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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