Autor: |
Eunji Lee, Huyeon Choi, L. Palanikumar, M. T. Jeena, Ja-Hyoung Ryu, Sooham Park, Yoo-Jeong Jeong |
Rok vydání: |
2016 |
Předmět: |
|
Zdroj: |
Chemical communications (Cambridge, England). 52(32) |
ISSN: |
1364-548X |
Popis: |
A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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