The HA-incorporated nanostructure of a peptide-drug amphiphile for targeted anticancer drug delivery

Autor:	Eunji Lee, Huyeon Choi, L. Palanikumar, M. T. Jeena, Ja-Hyoung Ryu, Sooham Park, Yoo-Jeong Jeong
Rok vydání:	2016
Předmět:	endocrine system endocrine system diseases Stereochemistry Disulfide Linkage Peptide Antineoplastic Agents 02 engineering and technology Tripeptide Conjugated system 010402 general chemistry 01 natural sciences Catalysis Amphiphile Materials Chemistry medicine heterocyclic compounds Hyaluronic Acid neoplasms chemistry.chemical_classification Microscopy Confocal Metals and Alloys General Chemistry Prodrug 021001 nanoscience & nanotechnology digestive system diseases 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nanostructures chemistry Ceramics and Composites Nanocarriers 0210 nano-technology Peptides Camptothecin medicine.drug
Zdroj:	Chemical communications (Cambridge, England). 52(32)
ISSN:	1364-548X
Popis:	A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec7809033582511d1897271668f5e79 https://pubmed.ncbi.nlm.nih.gov/27034247 Zobrazit plný text záznamu