Tracking Pattern of Total Cholesterol Levels from Childhood to Adolescence in Japan
| Autor: | Yuji Nishiwaki, Fumio Maejima, Kohta Suzuki, Eri Osawa, Tomonori Okamura, Keiko Asakura, Takeo Fujiwara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Time Factors Adolescent Cholesterol level 030204 cardiovascular system & hematology Body Mass Index Cohort Studies Tracking pattern 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors Japan Total cholesterol Internal Medicine Medicine Body Size Humans Child Coronary Artery Diseases Triglycerides Mixed effect model business.industry Biochemistry (medical) Age Factors Childhood Cholesterol Quartile Female Original Article Tracking (education) Artery diseases Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Demography |
| Zdroj: | Epub 2021 Jan 7 Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 |
| Popis: | Aims This study aimed to evaluate the tracking pattern of serum total cholesterol (TC) levels among Japanese children using data collected continuously for 9 years and examine the relationship between childhood and adulthood TC levels. Methods TC levels of 2,608 first grade primary school children enrolled during 1981-2014 from two Japanese towns were measured during annual health check-ups. Nine-year trajectories of estimated TC levels stratified by TC quartiles in the first grade were analyzed using a mixed effects model. Adulthood TC levels were measured in participants who underwent health check-ups in the same area. Results Overall, 1,322 boys and 1,286 girls in the first grade of a primary school were followed for 9 years. Trajectories of TC levels during the period stratified by TC quartiles in the first grade differed significantly and did not cross each other for both sexes. Childhood data of 242 adult participants were linked with their adulthood data; the mean of age was late 20s for both sexes. The average TC levels in adulthood increased from the first to the fourth quartile in the first grade. Additionally, trajectories of TC levels differed between boys and girls. The later the admission year, the more elevated the TC levels in girls. Conclusion Among Japanese children, TC levels were strongly tracked from childhood to adolescence for 9 years, and elevated TC levels in childhood were related to elevated TC levels in adulthood. Maintaining appropriate TC levels during childhood may be important to prevent future coronary artery diseases. |
| Databáze: | OpenAIRE |
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