Evaluation the Effect of Amine Type on the Non-isothermally Derived Activation Energy for the Interaction of 3 Antidepressant Drugs with Lactose
| Autor: | Faranak Ghaderi, Hadi Valizadeh, Mohammad Reza Siahi-Shadbad, Mahboob Nemati, Farnaz Monajjemzadeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Interaction
Solid-state Pharmaceutical Science Lactose 02 engineering and technology Activation energy Kinetic energy 01 natural sciences Isothermal process DSC chemistry.chemical_compound Differential scanning calorimetry medicine General Pharmacology Toxicology and Pharmaceutics Chemistry lcsh:RM1-950 021001 nanoscience & nanotechnology Doxepin 010406 physical chemistry 0104 chemical sciences Amine type lcsh:Therapeutics. Pharmacology Amine gas treating 0210 nano-technology Research Article Nuclear chemistry medicine.drug |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 9, Iss 2, Pp 289-293 (2019) Advanced Pharmaceutical Bulletin |
| ISSN: | 2251-7308 2228-5881 |
| Popis: | Purpose: Evaluation of drug-excipients compatibility is an important stage during preformulation studies. In the present research, differential scanning calorimetry (DSC) at different heating rates (2.5, 10, 15°C/min) was applied for the kinetic evaluation of fluvoxamine (FLM), sertraline (SER) and doxepin (DOX) binary mixtures with lactose. Methods: Solid state kinetic parameters of the mixtures were calculated using two different thermal methods including ASTM E698 and Starink and the effect of amine type (pKa value) was investigated based on the calculated activation energies. Results: Based on obtained results mean activation energy calculated for FLM, SER and DOX with lactose using ASTM E698 and Starink methods are equal to 335.23, 132.02 and 270.99 kJ/ mol respectively. Conclusion: Results showed that the probability of drug-lactose interaction is higher in the SERlactose mixture in comparison with other two antidepressant drugs which is consistent with their pKa values. |
| Databáze: | OpenAIRE |
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