Identification of a Novel HIV-1 Unique CRF01_AE/C Recombinant in Yan'an City, Shaanxi Province
| Autor: | Yan-Ping Chen, Xin Chen, Ying-Na Xie, Li-Li Gao, Feng Qi, Yan-Heng Zhou, Na Wang, Si-Wei Cheng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
China Genotype Immunology Human immunodeficiency virus (HIV) HIV Infections Genome Viral Biology medicine.disease_cause Genome law.invention 03 medical and health sciences 0302 clinical medicine law Virology medicine Humans 030212 general & internal medicine Phylogeny Genetics Recombination Genetic Genetic diversity Molecular epidemiology Strain (biology) virus diseases 030104 developmental biology Infectious Diseases Transmission (mechanics) Recombinant DNA HIV-1 Identification (biology) Female |
| Zdroj: | AIDS research and human retroviruses. 36(11) |
| ISSN: | 1931-8405 |
| Popis: | A wide variety of HIV-1 recombinants are constantly discovered in China. Comprehensively monitoring the genetic diversity of HIV-1 is very essential for understanding the molecular epidemiology and controlling the spread of the HIV-1 epidemic. In this study, we presented a novel HIV-1 unique CRF01_AE/C recombinant (19YA001) isolated from a female patient infected HIV-1 through heterosexual transmission in Yan'an city, Shaanxi province. The near full-length genome analyses showed 19YA001 was divided into two CRF01_AE and one C segments by two breakpoints observed in the vif/vpr region. To date, this is the first report revealing the characteristic of HIV-1 subtype in Yan'an city. And this unique recombinant strain might imply that the genetic diversity of HIV-1 in Yan'an city is complex. However, the sample size is too small. Further larger studies of HIV-1 molecular epidemiology are urgently needed to provide a better understanding of HIV-1 diversity and transmission in this region. |
| Databáze: | OpenAIRE |
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