Role and Function of O-GlcNAcylation in Cancer
| Autor: | Kyoung Ho Pyo, Hye Ryun Kim, Jii Bum Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Tumor microenvironment biology immune surveillance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Review O-GlcNAcase medicine.disease Receptor tyrosine kinase Metastasis Immune system O-GlcNAcylation Oncology cellular stress Cancer cell O-GlcNAc transferase medicine biology.protein Cancer research cancer Glycolysis Reprogramming RC254-282 |
| Zdroj: | Cancers Cancers, Vol 13, Iss 5365, p 5365 (2021) |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary Despite the rapid advancement in immunotherapy and targeted agents, many patients diagnosed with cancer have poor prognosis with dismal overall survival. One of the key hallmarks of cancer is the ability of cancer cells to reprogram their energy metabolism. O-GlcNAcylation is an emerging potential mechanism for cancer cells to induce proliferation and progression of tumor cells and resistance to chemotherapy. This review summarizes the mechanism behind O-GlcNAcylation and discusses the role of O-GlcNAcylation, including its function with receptor tyrosine kinase and chemo-resistance in cancer, and immune response to cancer and as a prognostic factor. Further pre-clinical studies on O-GlcNAcylation are warranted to assess the clinical efficacy of agents targeting O-GlcNAcylation. Abstract Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or increase in cellular stress results in the proliferation, progression, and metastasis of cancer cells. Notably, cancer is one of the emerging diseases associated with O-GlcNAcylation. In this review, we summarize studies that delineate the role of O-GlcNAcylation in cancer, including its modulation in metastasis, function with receptor tyrosine kinases, and resistance to chemotherapeutic agents, such as cisplatin. In addition, we discuss the function of O-GlcNAcylation in eliciting immune responses associated with immune surveillance in the tumor microenvironment. O-GlcNAcylation is increasingly accepted as one of the key players involved in the activation and differentiation of T cells and macrophages. Finally, we discuss the prognostic role of O-GlcNAcylation and potential therapeutic agents such as O-linked β-N-acetylglucosamine-transferase inhibitors, which may help overcome the resistance mechanism associated with the reprogramming of glucose metabolism. |
| Databáze: | OpenAIRE |
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