Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea
| Autor: | Geraldo Busatto-Filho, Carlos Alberto Buchpiguel, Linda M Ueno-Pardi, E. R. Barbosa, Renan S Guerra, Marta F. Lima, Paulo Jannuzzi Cunha, Denise M. L. Lobo, Geraldo Lorenzi-Filho, Thiago T Goya, Rosyvaldo F Silva, Carlos Eduardo Negrão |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic Nervous System Polysomnography Rest Blood Pressure 030204 cardiovascular system & hematology Arousal 03 medical and health sciences Executive Function 0302 clinical medicine Heart Rate Physiology (medical) Internal medicine Heart rate medicine Humans Attention COGNIÇÃO (AVALIAÇÃO) Aged Sleep Apnea Obstructive Mini–Mental State Examination medicine.diagnostic_test business.industry Muscles Microneurography Middle Aged medicine.disease respiratory tract diseases Obstructive sleep apnea Inhibition Psychological Blood pressure Case-Control Studies Stroop Test Physical therapy Cardiology Female Neurology (clinical) business Sleep Disordered Breathing Body mass index 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | STUDY OBJECTIVES To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA). METHODS Individuals with no other comorbidities (age = 52 ± 1 y, body mass index = 29 ± 0.4, kg/m2) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT. RESULTS Control and OSA groups (apnea-hypopnea index, AHI = 8 ± 1 and 47 ± 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O2 saturation (r = -0.57). CONCLUSIONS As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov, registration number: NCT002289625. |
| Databáze: | OpenAIRE |
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