Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected withHelicobacter pylori
| Autor: | Spencer Lm Payão, Lucas Trevizani Rasmussen, Marília de Ac Smith, Gustavo Arruda Viani, Agostinho Caleman Neto, Roger Willian de Labio, Valdeir Fagundes de Queiroz |
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| Přispěvatelé: | Marília Medical School FAMEMA Blood Center Department of Genetics, Sacred Heart University, Marília Medical School Department of Digestive System Surgery, Universidade Federal de São Paulo (UNIFESP), Marília Medical School Department of Radiotherapy and Oncology, FAMEMA Hemocentro Laboratório de Genética |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962 Rapid urease test Chronic gastritis Toxicology lcsh:RA1190-1270 lcsh:Zoology Genotype Biopsy medicine lcsh:QL1-991 Polymorphism lcsh:Toxicology. Poisons medicine.diagnostic_test biology Helicobacter pylori business.industry Research Interleukin biology.organism_classification medicine.disease Infectious Diseases Immunology Animal Science and Zoology Parasitology Gene polymorphism Gastritis medicine.symptom business |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases v.20 2014 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 20, Iss 0 (2014) Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 20, Article number: 17, Published: 20 MAY 2014 The Journal of Venomous Animals and Toxins Including Tropical Diseases Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| Popis: | Background: Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. The genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples. Result: H. pylori was detected in 30/60 patients (50%) by PCR. As for polymorphism of interleukin 8 (-251) gene we observed a statistical difference when analyzed TA (p = 0.039) and TT (p = 0.047) genotypes. In the IL1B31 there was a statistical difference in TT (p = 0.01) genotype and in theIL1B-511 there wasn’t any statistical difference. Conclusion: Our results suggest a strong correlation between the presence of chronic gastritis and infection byH. pylori and that IL1B-31TT and IL8-251TT genotypes appear to act as protective factors againstH. pylori infection while IL8-251TA genotype may comprise a risk factor for infection with this bacterium. Marília Medical School FAMEMA Blood Center Department of Genetics Sacred Heart University Marília Medical School Department of Digestive System Surgery Federal University of São Paulo Department of Morphology Marília Medical School Department of Radiotherapy and Oncology FAMEMA Hemocentro Laboratório de Genética UNIFESP, Department of Morphology SciELO |
| Databáze: | OpenAIRE |
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