Experimental modeling of the acute toxicity and cytogenotoxic fate of composite mixtures of chromate, copper and arsenate oxides associated with CCA preservative using Clarias gariepinus (Burchell 1822)
| Autor: | Chibuisi G. Alimba, Adekunle A. Bakare, Olukunle S. Fagbenro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Clarias gariepinus
micronucleus test antagonistic and synergistic interactions joint-action toxicity models metal mixtures acute toxicity 0211 other engineering and technologies chemistry.chemical_element 02 engineering and technology 010501 environmental sciences 01 natural sciences chemistry.chemical_compound Chromium GE1-350 Chromated copper arsenate Arsenic 0105 earth and related environmental sciences 021110 strategic defence & security studies biology Chromate conversion coating Arsenate biology.organism_classification Acute toxicity Environmental sciences chemistry Environmental chemistry Original Article Metalloid |
| Zdroj: | Environmental Health and Toxicology, Vol 34, Iss 3 (2019) Environmental Health and Toxicology, 34(3):e2019010 Environmental Analysis, Health and Toxicology |
| ISSN: | 2233-6567 |
| Popis: | Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed for adequate understanding of the health risk they may pose to biota. Clarias gariepinus was exposed to As2O3 , CrO3 and CuO and their composite mixtures (1:1 and 1:1:1) at various concentrations (0 – 600 mg/L) for 96-h to determine the acute toxicity using OECD (1992) protocol. C. gariepinus was then exposed to sub-lethal concentrations corresponding to 6.25, 12.5, 25.0, 50.0 and 100% of the 96-h LC50 for 7 days to assess the cytogenotoxic effects using piscine micronucleus (MN) test. The 96-h LC50 showed that the metals/metalloid demonstrated differential interactions in a concentration dependent pattern. The 96-h LC50 showed that Cr was the most toxic while Cu and As:Cu were indeterminate (Cr > Cr:Cu > As:Cr > As > As:Cr:Cu > Cu = As:Cu indeterminate). Isobologram and synergistic ratio (SR) models predicted antagonistic interaction between Cu:Cr and As:Cr and synergism between As:Cu in the causation of morbidity and mortality of C. gariepinus. Interaction factor model predicted antagonism as common interactive mechanism among the metal/metalloid mixtures in the induction of MN and abnormal nuclear erythrocytes in C. gariepinus. Predicted interactions among the three metals/ metalloid were largely antagonism and synergism towards the induction of acute toxicity and cytogenotoxicity. The models employed herein may be useful in establishing environmental safe limits for mixtures of metals/metalloids against the induction of acute toxicity and DNA damage in lower aquatic vertebrates. |
| Databáze: | OpenAIRE |
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