Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats
| Autor: | Gregg A. Dean, Wayne A. F. Tompkins, Mary Jo Burkhard, Loretta Valenski, Sarah Leavell |
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| Rok vydání: | 2002 |
| Předmět: |
Feline immunodeficiency virus
animal diseases viruses Genetic Vectors Alphavirus Immunodeficiency Virus Feline Recombinant virus Antibodies Viral T-Lymphocytes Regulatory Virus Encephalitis Virus Venezuelan Equine Viral Envelope Proteins T-Lymphocyte Subsets Feline Acquired Immunodeficiency Syndrome Animals Viremia Glycoproteins Vaccines Synthetic CATS General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health virus diseases Viral Vaccines biochemical phenomena metabolism and nutrition biology.organism_classification Virology Infectious Diseases Evaluation Studies as Topic Humoral immunity Lentivirus Immunology Vagina biology.protein Cats Molecular Medicine Female Antibody T-Lymphocytes Cytotoxic |
| Zdroj: | Vaccine. 21(3-4) |
| ISSN: | 0264-410X |
| Popis: | Venezuelan equine encephalitis (VEE) virus-replicon particles (VRP) were used to generate feline immunodeficiency virus (FIV) Gag- and ENV-expressing vaccine vectors. Serum and mucosal FIV-specific antibody was detected in cats immunized subcutaneously, once monthly for 5 months, with FIV-expressing VRP. Expansion of the CD8+ L-selectin negative phenotype and transient CD8+ noncytolytic suppressor activity were seen in cats immunized with FIV-expressing or control VRP. Despite induction of FIV-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSU(1) although relative early maintenance of CD4+ cells was seen in FIV-immunized cats. |
| Databáze: | OpenAIRE |
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