Serum Endocan, Neuron-Specific Enolase and Ischemia-Modified Albumin Levels in Newborns with Partial Blood Exchange Transfusion
| Autor: | Utku Serkant, Erbu Yarci, Ufuk Cakir, Cuneyt Tayman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Enolase Ischemia Exchange Transfusion Whole Blood Hyperviscosity Serum Albumin Human Polycythemia Gastroenterology Internal medicine Drug Discovery Medicine Humans business.industry Organic Chemistry Ischemia-modified albumin Infant Newborn Blood exchange transfusion General Medicine Blood flow medicine.disease Computer Science Applications Neoplasm Proteins Phosphopyruvate Hydratase Biomarker (medicine) Tissue hypoxia Proteoglycans business Biomarkers |
| Zdroj: | Combinatorial chemistryhigh throughput screening. 24(6) |
| ISSN: | 1875-5402 |
| Popis: | Background:: Hyperviscosity of blood secondary to polycythemia results in increased resistance to blood flow and decrease in delivery of oxygen. Objective:: To evaluate whether serum endocan, NSE and IMA levels can be compared in terms of endothelial injury/ dysfunction and neuronal damage in term neonates with polycythemia who underwent PET. Methods:: 38 symptomatic polycythemic newborns having PET and 38 healthy newborns were included in the study. Blood samples for endocan, NSE and IMA were taken at only postnatal 24 hours of age in the control group and in polycytemia group just before PET, at 24 and 72 hours after PET. Results:: The polycythemia group had higher serum endocan(1073,4 ± 644,8 vs. 378,8 ± 95,9ng/ml; p0.05). At 72 hours after PET the polycythemia and control groups did not differ statistically for IMA, endocan and NSE levels (p>0.05). Conclusion:: Serum endocan and IMA levels can be used as a biomarker for endothelial damage/ dysfunction and tissue hypoxia in infants with symptomatic polycytemia. |
| Databáze: | OpenAIRE |
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