Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
| Autor: | Silvana Obici, Zhaohui Feng, George B. Karkanias, Luciano Rossetti, Daniel T. Stein, Kimyata Morgan |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Potassium Channels Endocrinology Diabetes and Metabolism Central nervous system Hypothalamus Neuropeptide Rats Sprague-Dawley Eating chemistry.chemical_compound Adenosine Triphosphate Internal medicine Potassium Channel Blockers Internal Medicine medicine Animals Insulin Neuropeptide Y Injections Intraventricular Third Ventricle chemistry.chemical_classification Leptin digestive oral and skin physiology Fatty acid Metabolism Rats Oleic acid Glucose Sulfonylurea Compounds medicine.anatomical_structure Endocrinology chemistry Anorectic Oleic Acid |
| Zdroj: | Diabetes. 51:271-275 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diabetes.51.2.271 |
| Popis: | The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K+ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation. |
| Databáze: | OpenAIRE |
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