Value of Plasmatic Villin-1 in the Prediction of Early Graft Dysfunction in Kidney Transplant Recipients: Diagnostic Accuracy Test
| Autor: | Nahla Mohamed Teama, Mohamed Ali Ezzat, Mohamed El Tayeb Nasser, Hesham Atef Abou Elleil, Waleed Anwar Abdel Mohsen |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Graft dysfunction Urology Delayed Graft Function Reference range Diagnostic accuracy Urine chemistry.chemical_compound medicine Humans Transplantation Creatinine biology business.industry Microfilament Proteins Acute kidney injury Acute Kidney Injury medicine.disease Kidney Transplantation chemistry biology.protein Biomarker (medicine) Villin business Biomarkers |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 19(2) |
| ISSN: | 2146-8427 |
| Popis: | OBJECTIVES One of the complications of kidney transplant is delayed graft function. Villin-1 has been detected in urine of patients with acute kidney injury. In addition, it is redistributed during acute kidney injury from the brush borders of the proximal tubular cells toward the basolateral membrane, which positions villin-1 closer to the renal vasculature, suggesting that it could be also released in the blood and thus can be a novel biomarker for delayed graft function. MATERIALS AND METHODS In this diagnostic accuracy test multicenter study, 41 patients undergoing kidney transplant and attending renal transplant clinics were assigned into 2 groups according to serum creatinine levels during the first 2 days posttransplant: delayed graft function group and normal graft function group. We measured plasmatic villin-1 in comparison to serum creatinine levels at the time of declamping (time 0) and at 1, 3, 5, 7, 12, 24, 48, 72, 96, and 120 hours after declamping. RESULTS Statistically significant differences were noted in comparisons between groups at same time points with regard to plasmatic villin-1 levels; also, plasmatic villin-1 started to increase above reference range in patients with end-stage renal disease at 5 hours after declamping; a peak was shown at hour 7 in the delayed graft function group, which decreased but did not reach the reference range until 120 hours after declamping. CONCLUSIONS Plasmatic villin-1 is a promising novel biomarker for detection of early graft dysfunction in kidney transplant recipients. |
| Databáze: | OpenAIRE |
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