The role of human papillomavirus in laryngeal cancer in Southern China
| Autor: | Michael M.H. Chan, Amy B.W. Chan, Joanna H.M. Tong, Ka Fai To, Martin C.S. Wong, Zigui Chen, Eddy W.H. Lam, Apple C.M. Yeung, Cynthia K C Wai, Paul K.S. Chan, Chi Man Ngai |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Recurrence Virology Internal medicine Medicine Humans Papillomaviridae Laryngeal Neoplasms Survival analysis Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Aged 80 and over biology business.industry Surrogate endpoint Cancer Retrospective cohort study Laryngeal Neoplasm Middle Aged biology.organism_classification medicine.disease Immunohistochemistry Survival Analysis 030104 developmental biology Infectious Diseases Cross-Sectional Studies Otorhinolaryngology 030220 oncology & carcinogenesis DNA Viral Carcinoma Squamous Cell Hong Kong Female Tumor Suppressor Protein p53 business |
| Zdroj: | Journal of medical virology. 90(6) |
| ISSN: | 1096-9071 |
| Popis: | To delineate the role of human papillomavirus (HPV) in laryngeal cancer in Southern Chinese, a retrospective cross-sectional study was conducted in a major otorhinolaryngology referral center in Hong Kong. Eighty-five Chinese patients with histology-confirmed laryngeal squamous cell carcinoma (LSCC) diagnosed between 2005 and 2010 were examined for the status of HPV by PCR, and the expression of p16 and p53 by immunohistochemistry. The HPV, p16 and p53 findings were correlated with clinicopathological features, recurrence and 5-year survival. HPV DNA was detected in one patient (1.2%, 95%CI: 0.2-6.4%) who had glottic cancer and harbored HPV-6. Overexpression of p16 and p53 were detected in 11 (12.9%) and 47 (55.3%) cases, respectively. Recurrence occurred in 22.4% of patients at a median of 13 months. The 5-year overall survival and disease-specific survival were 55.7% and 72.4%, respectively. Overexpression of p16 or p53 was not associated with clinicopathological features, recurrence or overall survival. HPV plays a limited role in laryngeal cancer in Hong Kong Southern Chinese. In contrast to oropharyngeal cancer, p16 cannot be used as a surrogate marker for oncogenic involvement of HPV and cannot predict survival in laryngeal cancer. |
| Databáze: | OpenAIRE |
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