In ovariectomy-induced osteoporotic rat models, BMP-2 substantially reversed an impaired alveolar bone regeneration whereas PDGF-BB failed
| Autor: | Kyoung-Hwa Kim, In-Chul Rhyu, Yong-Moo Lee, Young Ku, Hyun-Ju Kim, Yang-Jo Seol |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bone Regeneration Platelet-derived growth factor Ovariectomy Osteoporosis Rat model Becaplermin Bone Morphogenetic Protein 2 Postmenopausal osteoporosis Bone morphogenetic protein 2 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Transforming Growth Factor beta Internal medicine medicine Animals Humans General Dentistry Dental alveolus biology business.industry Regeneration (biology) Proto-Oncogene Proteins c-sis 030206 dentistry medicine.disease Recombinant Proteins Rats Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein Female business Platelet-derived growth factor receptor |
| Zdroj: | Clinical Oral Investigations. 25:6159-6170 |
| ISSN: | 1436-3771 1432-6981 |
| DOI: | 10.1007/s00784-021-03915-7 |
| Popis: | We previously suggested an ovariectomy (OVX)-induced osteoporotic rat model showing an impaired alveolar bone defect healing. This study aimed to evaluate and compare the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) on alveolar bone defect healing in OVX-induced osteoporotic rats. A total of forty-one female rats were divided into four groups: a collagen group (n=10), a PDGF-BB group (n=11), a BMP-2 group (n=10), and a control group (n=10). Four months after OVX, alveolar bone drill-hole defects were created and grafted with collagen gel, rhPDGF-BB/collagen gel, or rhBMP-2/collagen gel. The defects in the control group were not grafted with any material. Defect healing was evaluated by histological, histomorphometric, and microcomputed tomographic (micro-CT) analyses at 2 and 4 weeks. According to the micro-CT analysis, the BMP-2 group exhibited the greatest bone volume fraction among all groups, while the PDGF-BB group did not show significant differences compared with the collagen group. The histomorphometric analysis showed a significantly larger amount of new bone area in the BMP-2 group than in the control and collagen groups at 4 weeks; however, the PDGF-BB group did not reach significant superiority compared with the other groups. Alveolar bone regeneration was significantly enhanced by the local use of rhBMP-2/collagen gel compared with the use of rhPDGF-BB/collagen gel in OVX-induced osteoporotic rats. A treatment modality using rhBMP-2 may be a promising approach to promote alveolar bone regeneration in patients suffering from postmenopausal osteoporosis. |
| Databáze: | OpenAIRE |
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