A new investigative strategy to diagnose β-thalassemia syndrome in past human populations
| Autor: | Barbara Bramanti, Emanuela Gualdi-Russo, Filippo Scianò |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Archeology
medicine.medical_specialty Paleopathology Disease Thalassemia syndrome 03 medical and health sciences hemic and lymphatic diseases medicine 0601 history and archaeology LS4_8 030304 developmental biology Anthropology Archaeology Forensic Paleopathology beta-thalassemia syndrome beta-thalassemia syndrome 0303 health sciences 060101 anthropology business.industry Forensic Ambientale 06 humanities and the arts SH6_1 Dermatology Skull medicine.anatomical_structure Archaeology Bone lesion Anthropology Identification (biology) Best evidence business |
| Zdroj: | Archaeological and Anthropological Sciences. 13 |
| ISSN: | 1866-9565 1866-9557 |
| Popis: | The study of thalassaemia syndromes in archeological human remains is of growing interest in the field of paleopathology. However, a definitive diagnosis of the disease in skeletonized individuals remains difficult. Several non-specific bone lesions have been suggested as the most likely evidence of β-thalassaemia syndrome. In particular, skull lesions have been considered by several scholars as the most indicative of this hematopoietic disorder, while other authors have identified postcranial lesions as the best evidence of β-thalassemia. In this study, we reviewed the main features that have been identified in β-thalassaemia patients thanks to an extensive bibliographic research of clinical cases, radiological and microscopic analyses. Our aim was to discern between those skeletal lesions that can be considered “indicative/diagnostic” and those that are “indicative/non-diagnostic” of β-thalassaemia syndrome. With this knowledge, we developed a new evaluation form (Eva-BeTa) and tested it on previously published archeological cases. Based on our results, we believe that Eva-BeTa can be a valid diagnostic tool for the identification of ancient individuals potentially affected by β-thalassemia for further genetic confirmation. |
| Databáze: | OpenAIRE |
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