| Autor: |
Hakan Ekmekçi, Gülnur Tekgöl Uzuner, Burcu Zeydan, Bijen Nazliel, Cemile Handan Misirli, Arda Yilmaz, Ipek Midi, Mehmet Güney Şenol, Nevzat Uzuner, Serkan Demir, Taskin Duman, Mehmet Yaman, Şerefnur Öztürk, Hakan Tekeli, Uygar Utku, Ahmet Tufekci, Nazire Afsar, Necdet Mengulluoglu, Nilufer Yesilot, Mustafa Acikgoz, Baki Göksan, Ozgur Osman Yalin, Firdevs Ezgi Ucan Tokuc, Seden Demirci, Aysel Milanlioglu, Fusun Mayda Domac, Hamit Genc, Mustafa Bakar, Nilgun Cinar, Emrah Aytaç, Nida Tascilar, Sevim Baybaş, Hale Zeynep Batur Caglayan, Sena Colakoglu, Dilek Necioglu Orken, Derya Uluduz, Serdar Oruc, Eylem Ozaydin Goksu, Fatih Ozdag, Vedat Ali Yürekli, Birsen Ince, Hesna Bektas, Yüksel Kablan, Hasan Hüseyin Kozak, Ali Yavuz Karahan, Vildan Yayla, Özge Yilmaz Kuspeci, Hayriye Kucukoglu, Murat Çabalar, Mustafa Gokce, Ufuk Aluclu, Başak Karakurum Göksel |
| Přispěvatelé: |
Zonguldak Bülent Ecevit Üniversitesi, Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı., Bakar, Mustafa, Maltepe Üniversitesi, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tüfekçi, Ahmet |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Popis: |
WOS: 000407019200036
PubMed ID: 28583818
Background: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. (c) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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