Infection studies with canine distemper virus in harbour seals
| Autor: | Erik D. Lund, Vilhjálmur Svansson, N. I. Heje, P. Have, Merete Blixenkrone-Møller, K. Skirnisson, Jens Nielsen |
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| Rok vydání: | 1993 |
| Předmět: |
Time Factors
Paramyxoviridae Lymphoid Tissue Seals Earless animal diseases viruses Biology Antibodies Viral Virus Replication Phoca Virus Cytopathogenic Effect Viral Morbillivirus Neutralization Tests Virology biology.animal Leukocytes medicine Animals Lymphocytes Viremia Distemper Mink Antigens Viral Distemper Virus Canine Vero Cells Cells Cultured Canine distemper virus diseases General Medicine biology.organism_classification medicine.disease Immunoglobulin M Viral replication Immunoglobulin G Viral disease |
| Zdroj: | Archives of Virology. 131:349-359 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/bf01378637 |
| Popis: | Infection studies in harbour seal (Phoca vitulina) were conducted with the Snyder-Hill strain of canine distemper virus (CDV) that is virulent for dog and mink. The inoculated seals showed clinical symptoms which were to some degree similar to those observed in CDV infections of sensitive species of carnivores. Viral replication in lymphoid cells was followed by an extended period of immunosuppression. The results did not provide conclusive evidence for viral replication in surface epithelia of seals, and accordingly no spread of the infection to contact seals and mink was demonstrated. The pathogenicity of the infection did not increase upon a second viral passage in seal. The serological data showed that CDV-infected seals mounted an early virus specific antibody response. Overall, the results indicated that the harbour seal was not especially sensitive to CDV infection. The differences in the in vivo biological properties of CDV and PDV add to the distinction between these viruses at the genomic and antigenic levels. |
| Databáze: | OpenAIRE |
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