Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity
| Autor: | Frédéric Frézard, Cynthia Demicheli, Carlos A. de Simone, Ludmila Gonçalvez de Oliveira, Meiriane Mariano da Silva, Claudio Luis Donnici, Eufrânio N. da Silva Júnior, Elene C. Pereira-Maia, Flávia C. S. de Paula |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Antimony
Magnetic Resonance Spectroscopy antimony(V) complex Stereochemistry Molecular Conformation Pharmaceutical Science chemistry.chemical_element Crystal structure Crystallography X-Ray Medicinal chemistry Article Analytical Chemistry Bismuth lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry bismuth(V) complex lapachol cytotoxicity cancer Drug Discovery Humans Cytotoxic T cell Physical and Theoretical Chemistry Cell Proliferation Lapachol Cell Death Chemistry Organic Chemistry Nuclear magnetic resonance spectroscopy Middle Aged Monomer Chemistry (miscellaneous) Molecular Medicine Female K562 Cells Derivative (chemistry) Naphthoquinones |
| Zdroj: | Molecules Molecules, Vol 16, Iss 12, Pp 10314-10323 (2011) Molecules; Volume 16; Issue 12; Pages: 10314-10323 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules161210314 |
| Popis: | Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph3SbCl2 or Ph3BiCl2 with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bismuth atoms. The antimony(V) complex is a monomeric derivative, (Lp)(Ph3Sb)OH, and the bismuth(V) complex is a dinuclear compound bridged by an oxygen atom, (Lp)2(Ph3Bi)2O. Both compounds inhibited the growth of a chronic myelogenous leukemia cell line and the complex of Bi(V) was about five times more active than free lapachol. This work provides a rare example of an organo-Bi(V) complex showing significant cytotoxic activity. |
| Databáze: | OpenAIRE |
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