Suppression of frontal eye field neuronal responses with maintained fixation
| Autor: | James W. Bisley, Koorosh Mirpour, Zeinab Bolandnazar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
genetic structures
media_common.quotation_subject Fixation Ocular Stimulus (physiology) Basic Behavioral and Social Science 050105 experimental psychology frontal eye field 03 medical and health sciences 0302 clinical medicine Ocular Perception Behavioral and Social Science Saccades Animals 0501 psychology and cognitive sciences Prefrontal cortex Eye Disease and Disorders of Vision media_common search Multidisciplinary 05 social sciences Neurosciences Eye movement oculomotor Biological Sciences Fixation Macaca mulatta eye diseases Frontal Lobe eye movements Receptive field Neurological Saccade Fixation (visual) sense organs Single trial Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 4 |
| ISSN: | 1091-6490 |
| Popis: | The decision of where to make an eye movement is thought to be driven primarily by responses to stimuli in neurons' receptive fields (RFs) in oculomotor areas, including the frontal eye field (FEF) of prefrontal cortex. It is also thought that a saccade may be generated when the accumulation of this activity in favor of one location or another reaches a threshold. However, in the reading and scene perception fields, it is well known that the properties of the stimulus at the fovea often affect when the eyes leave that stimulus. We propose that if FEF plays a role in generating eye movements, then the identity of the stimulus at fixation should affect the FEF responses so as to reduce the probability of making a saccade when fixating an item of interest. Using a visual foraging task in which animals could make multiple eye movements within a single trial, we found that responses were strongly modulated by the identity of the stimulus at the fovea. Specifically, responses to the stimulus in the RF were suppressed when the animal maintained fixation for longer durations on a stimulus that could be associated with a reward. We suggest that this suppression, which was predicted by models of eye movement behavior, could be a mechanism by which FEF can modulate the temporal flow of saccades based on the importance of the stimulus at the fovea. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|